Microbiome Networks:Network models of soil and plant microbiomes present new opportunities for enhancing disease management, but also challenges for interpretation. We present a framework for interpreting microbiome networks, illustrating how the observed structure of networks can be used to generate testable hypotheses about candidate microbes affecting plant health. The framework includes four types of network analyses.“General network analysis” identifies candidate taxa to maintain an existing microbial community. “Host-focused analysis” includes a node representing a plant response such as yield, identifying taxa with direct or indirect links to that node, interpreted as either beneficial or detrimental to plant health. “Pathogen-focused analysis” identifies taxa with direct or indirect links to taxon nodes known a priori to represent pathogens, which can be interpreted as agonists and antagonists, respectively. “Disease-focused analysis” identifies key nodes for both plant and pathogen responses.