Welcome to Cancer Driver Catalog !

With the development of next generation–sequencing technology, diversified computational methods based on mutational frequencies, network, and function approaches, have been developed to identify mutational driver genes in the cancer genome. However, the candidate driver genes identified by different software are separately presented, which are inconvenient for general clinicians and researches to obtain the first-hand information of candidate driver genes predicted by different bioinformatics methods. Herein, after evaluating the performance of 12 computational methods using datasets of PCAWG and TCGA, we integrated the genes, corresponding possibility scores, and the rank of gene in the candidate driver gene list predicted by 12 computational methods using 6 network datasets (for network-based methods) across pan-cancer and 36 cancer types in this website. The higher the rank of a gene, the more likely it is to be a real cancer driver. By employing this website, users can conveniently search the candidate driver genes identified by these 12 methods in pan-cancer and 36 cancer types.


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Abbreviation Cancer
ACC Adrenocortical carcinoma
BLCA Bladder Urothelial Carcinoma
BRCA Breast invasive carcinoma
CESC Cervical squamous cell carcinoma and endocervical adenocarcinoma
CHOL Cholangiocarcinoma
COAD Colon adenocarcinoma
COADREAD Colon adenocarcinoma/Rectum adenocarcinoma Esophageal carcinoma
DLBC Lymphoid Neoplasm Diffuse Large B-cell Lymphoma
ESCA Esophageal carcinoma
GBM Glioblastoma multiforme
GBMLGG Glioma
HNSC Head and Neck squamous cell carcinoma
KICH Kidney Chromophobe
KIPAN Pan-kidney cohort (KICH+KIRC+KIRP)
KIRC Kidney renal clear cell carcinoma
KIRP Kidney renal papillary cell carcinoma
LAML Acute Myeloid Leukemia
LGG Brain Lower Grade Glioma
LIHC Liver hepatocellular carcinoma
LUAD Lung adenocarcinoma
LUSC Lung squamous cell carcinoma
OV Ovarian serous cystadenocarcinoma
PAAD Pancreatic adenocarcinoma
PCPG Pheochromocytoma and Paraganglioma
PRAD Prostate adenocarcinoma
READ Rectum adenocarcinoma
SARC Sarcoma
SKCM Skin Cutaneous Melanoma
STAD Stomach adenocarcinoma
STES Stomach and Esophageal carcinoma
TGCT Testicular Germ Cell Tumors
THCA Thyroid carcinoma
THYM Thymoma
UCEC Uterine Corpus Endometrial Carcinoma
UCS Uterine Carcinosarcoma
UVM Uveal Melanoma
PCAWG pan-cancer