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Motivation of AddictGene

Addiction, a chronic, relapsing brain disease, is characterized by loss of control over psychostimulant drug intake and compulsive drug consumption despite serious adverse consequences. Alteration of gene expression has been linked to dependence, withdrawal, and relapse of psychostimulant-dependent individuals in both animal and human studies. As the gene expression data relating to changes induced by psychostimulants are accumulating rapidly in last decade, there is a growing need to integrate and annotate the current multi-omic data from multiple studies for convenient retrieval by bench researchers and clinicians. To fulfill this need, AddictGene is thus developed. AddictGene integrated gene expression, gene-gene interaction, gene-drug interaction and regulatory annotation for over 33,821 items of differentially expressed genes associated with psychostimulants across three species (human, mouse, rat) from 205 publications. Importantly, it contains 1,010 addiction-associated genes that have been experimentally validated by RT-PCR, Northern blot, and in situ hybridization.



Data scheme of AddictGene

workflow picture

Information integrated in AddictGene

AddictGene presents a friendly web interface to allow user search and browse detailed gene study information of drug addiction (e.g. substance, species, techniques, drug treatment, tissue/cell, fold changes of gene expression, P-values et.al.). Moreover, AddictGene is a useful tool for browse and view of multidimensional data associated with the identified differentially expressed genes:

  1. Gene-related disorders including substance dependence and disease;
  2. Expression alteration of specific gene in other psychiatric disorders;
  3. Expression patterns of interested gene across 31 primary and 54 secondary human tissues;
  4. Functional annotation of interested gene;
  5. Two kinds of potential epigenetic regulators involved in the alteration of specific genes, including histone modifications and DNA methylation;
  6. Protein-Protein interaction for functional linkage with interested gene;
  7. Drug-gene interaction for potential druggability.

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