SDM

SDM: a server for predicting effects of mutations on protein stability

Arun P. Pandurangan, Bernardo Ochoa-Montaño, David B. Ascher, Tom L. Blundell
Nucleic Acids Research, v. 45, Issue W1, Pages W229–W235, 2017

Abstract

Studying the effects of mutation on protein stability and function is important in understanding its role in disease. Site Directed Mutator (SDM) is a computational method that analyses the variation of amino acid replacements occuring at specific structural environment that are tolerated within the family of homologous proteins of known 3-D strucures and convert them into substitution probability tables. These tables are uses as a quantative measure for predicting the protein stability upon mutation. Here we report the improved and updated SDM web server.




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